The finding that fails your inspection is already in your data. You just haven't read it yet.
R1 is an AI oversight layer that reads across every system in your trial at once and surfaces the risk the day it appears - not weeks later when someone reconciles two logs by hand.
From Passive Oversight
To Active Control
The bar moved. You now must demonstrate oversight, not assert it.
ICH E6(R3) has been in effect since July 2025. The expectation is no longer that you have a monitoring plan. It is that you can show what was watched, what fired, who acted, and whether the action worked. Most oversight stacks can produce the plan. Far fewer can produce the record. And the gap between asserting oversight and demonstrating it is exactly where an inspector goes looking.
Those findings rarely sit in a dashboard. They live in the gaps between systems, and in the text nobody read end to end.
Four blind spots.
Every one of them surfaces at the worst possible time.
Your systems already hold all four. None of them reached you in time to act.
R1 reads what your systems already produce -
and reads it the day it lands.
R1 sits on top of the systems that already hold your data - EDC, CTMS, eTMF, IRT and eCOA - plus your deviation log and monitoring records. It reads across all of them at once, reconciles what one system says against another, reads the reports nobody finishes, and surfaces what crossed a line. Recent and critical first, in one prioritized view - not an undifferentiated dashboard.
Reads across every system
The risk lives between systems. R1 is the layer that reads all of them together.
Surfaces the crossing, not the noise
You see what changed and what it means - the day it happened.
Read-only. No burden on sites.
R1 changes nothing in your systems and asks nothing of your sites.
Built for the way sponsors and CROs actually work.
In active pilots with pharma sponsors and CROs
SOC 2-aligned controls
Read-only, one-time data transfer
Nothing for your sites to do
Your own thresholds, your own protocol rules
Your data stays in your environment
AI Agents, Built for Clinical Ops
Espresso plugs into your existing trial documents - no integrations, no new portals, no extra lift.
Connect
1. Connect Your Data
Upload reports, logs, and site notes. Espresso starts working right away.
Deploy
2. Deploy Intelligent Agents
AI begins tracking activity, surfacing risks, and suggesting follow-ups.
Monitor
3. Monitor in Real Time
You’ll see protocol issues and CRA actions as they happen -not days later.
SCALE
4. Scale and Standardize
Run more sites with less friction. Espresso keeps every trial aligned and audit-ready.
IMPROVE
5. Repeat with Confidence
Each trial makes the next one smarter. Build momentum across studies without resetting the wheel.
See what's hiding in a study you already ran.
Free, in four weeks.
Bring us a completed or in-flight study. In about four weeks we return a report that shows what R1 would have surfaced, when, and how much sooner than your own timeline caught it. A one-time, read-only data transfer. SOC 2-aligned controls. No cost, and nothing for your sites to do.
